In a move guaranteed to raise ethical questions around the world, scientists in California are using gene-editing techniques to remove parts of a pig’s DNA, then replace it with human DNA that codes for the human pancreas. It is their hope that this will provide a source to grow human organs, toi deal with the desperate shortage of transplantable organs currently available:
Researchers at the University of California, Davis combined human stem cells and pig DNA and allowed the embryos to mature for 28 days, before terminating the experiment and analyzing the tissue. They believe the animals, if they had been carried to term, would have developed a human internal organ, but would have looked and behaved like any other pig. The goal is that in the future, similar animals could potentially act as a ready source of organs for life-saving transplants.
Of course, the key ethics question is: how much human DNA can be added to a pig before the pig becomes “too human?” Getting the balance right will be the goal of future research, which nonetheless promises an exciting new advance in transplantation medicine.